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KMID : 1098420140220060457
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Korean Journal of Medicinal Crop Science
2014 Volume.22 No. 6 p.457 ~ p.462
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Prostaglandin E2 Up-regulation and Wound Healing Effect of the Ethanol Extract of Eriobotryae Folium in Human Keratinocyte
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Im Do-Youn
Lee Kyoung-In
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Abstract
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Prostaglandin (PG) E2 is an important mediator of skin wound healing without excessive scarring and gastric ulcer healing. However, PGE2 has a short lifetime in vivo because it is metabolized rapidly by 15-hydroxyprostaglandin dehydrogenase (15-PGDH). Ethanol extract of Eriobotryae folium (EFEE) elevated intracellular and extracellular PGE2 levels in HaCaT cells and inhibited 15-PGDH (ED50 : 168.4 ㎍/mL) with relatively low cytotoxicity (IC50 : 250.0 ㎍/mL). Real-time PCR analysis showed that mRNA expression of cyclooxygenase (COX)-1 and COX-2 enzymes were increased and prostaglandin transporter (PGT) was decreased in HaCaT cells by EFEE. Moreover, wound healing effect of EFEE (168.4 ㎍/mL) was comparable to that of TGF-β1 (300 pg/mL) as a positive control. These results demonstrate that EFEE may be valuable therapeutic materials for the treatment of PGE2 level dependent diseases.
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KEYWORD
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Eriobotryae Folium, Prostaglandin E2, Wound Healing
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